Inflammatory bowel disease (IBD): possible trigger discovered

Inflammatory bowel disease (IBD): Study finds potential trigger

Within a study Medical University of Vienna An Austrian research team has now found that the trigger for the development of chronic inflammatory bowel disease surface of intestinal epithelial cells Can lie. The discovery provides a new potential starting point in the treatment of chronic inflammatory bowel disease, which until now has primarily aimed to alleviate symptoms.

A research team led by Bernadette Motl and Robert Efferl observed that changes in the brush border of intestinal epithelial cells may be linked to the development of IBD. Intestinal epithelial cells are specialized cells that form the inner lining of the intestine. They are closely packed and form a barrier between the cavity inside the intestine and the surrounding tissue. If the intestinal epithelial cells change along with the infiltration of the mucosal layer, the risk of IBD increases. For example, the Eating unhealthy, high-fat foods Promotes permeability of the mucosal layer at the brush border of intestinal epithelial cells.

Also interesting: Frequent bowel movements can be a symptom of these diseases

What is IBD?

The two most common forms of IBD are Crohn's disease and ulcerative colitis. Crohn's disease It can affect any part of the digestive tract from the mouth to the anus, sometimes causing inflammation that penetrates deep into the intestinal wall. Possible symptoms for those affected include abdominal pain, diarrhea, weight loss, fatigue and bleeding.

One Colon ulcer Whereas, it primarily affects the colon and rectum, causing inflammation limited to the inner lining of the intestine. Typical symptoms include bloody diarrhea, abdominal pain and cramps, fever, and weight loss.

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